ENVIRONMENTAL AND BIOLOGICAL DETERMINANTS OF BRAIN MASS

Environmental and Biological Determinants of Brain Mass

According to the expensive brain hypothesis, periodic energy level determines the brain mass.However, various environmental and biological factors directly or indirectly relevant to energy intake have not been well studied.Here, we systematically examined how body itsmajorlook.com mass, hibernation, diurnally, substrate use, diet individually and s

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Effect of TP53 deficiency and KRAS signaling on the bioenergetics of colon cancer cells in response to different substrates: A single cell study

Metabolic reprogramming is a hallmark of cancer.Somatic mutations in genes involved in oncogenic signaling pathways, including KRAS and TP53, rewire the metabolic machinery in cancer cells.We here set out to determine, at the single cell level, metabolic signatures in human colon cancer cells engineered to express combinations of activating KRAS ge

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